The IAEA Secretariat is headquartered at the Vienna International Centre in Vienna, Austria. Operational liaison and regional offices are located in Geneva, Switzerland; New York, USA; Toronto, Canada; and Tokyo, Japan. The IAEA runs or supports research centers and scientific laboratories in Vienna and Seibersdorf, Austria; Monaco; and Trieste, Italy. (See Offices and Contacts).

The IAEA Secretariat is a team of 2200 multi-disciplinary professional and support staff from more than 90 countries. The Agency is led by Director General Yukiya Amano and six Deputy Directors General who head the major departments. (See IAEA Staff).

IAEA programmes and budgets are set through decisions of its policymaking bodies – the 35-member Board of Governors and the General Conference of all Member States. Reports on IAEA activities are submitted periodically or as cases warrant to the UN Security Council and UN General Assembly. (SeePolicy Bodies).

IAEA financial resources include the regular budget and voluntary contributions. The Regular Budget for 2008 amounts to € 277 million. The target for voluntary contributions to the Technical Co-operation Fund for 2008 is $80 million (as per the latest IAEA Annual Report).